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PHOSPHATASE, PEST-ENRICHED
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DeCS
Descriptor
English
:
Protein Tyrosine Phosphatase, Non-Receptor Type 12
Descriptor
Spanish
:
Proteína Tirosina Fosfatasa no Receptora Tipo 12
Descriptor
Portuguese
:
Proteína Tirosina Fosfatase não Receptora Tipo 12
Synonyms
English
:
PEP PTPase
PEP Protein Tyrosine Phosphatase
PEST-Enriched Phosphatase
PTP-PEST
PEST Enriched Phosphatase
PTPase, PEP
Phosphatase, PEST-Enriched
Protein Tyrosine Phosphatase, Non Receptor Type 12
Tree Number:
D08.811.277.352.650.775.300.850
D12.644.360.585.850
D12.776.476.564.850
Definition
English
:
A subtype of non-receptor
protein tyrosine phosphatases
that is characterized by the presence of a N-terminal
catalytic domain
and a large C-terminal domain that is enriched in
PROLINE
,
GLUTAMIC ACID
,
SERINE
, and
THREONINE
residues (PEST sequences). The phosphatase subtype is ubiquitously expressed and implicated in the regulation of a variety of biological processes such as
CELL MOVEMENT
;
CYTOKINESIS
; focal adhesion disassembly; and
LYMPHOCYTE ACTIVATION.
History Note
English
:
2008(1994)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
52701
Unique Identifier:
D054594
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS